Selected Publications

from a total of 110+ papers (with more than 15,000 citations as of Jan 08)    h-index 53 

Yao, Y., Harrison, C,. Freddolino, P., Schulten, K. and Mayer, M.L. (2008) Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. EMBO J 27: 2158-2170.

Plested, A.J., Vijayan, R., Biggin, P.C. and Mayer, M.L. (2008) Molecular Basis of Kainate Receptor Modulation by Sodium. Neuron 58, 720-735.

Plested, A.J. and Mayer, M.L. (2007) Structure and Mechanism of Kainate Receptor Modulation by Anions. Neuron 53, 829-841.

Weston, M.C., Schuck, P., Ghosal, A., Rosenmund, C. and Mayer, M.L. (2006) Conformational restriction blocks glutamate receptor desensitization. Nature Structural & Molecular Biology 13:1120-1127.

Weston, M.C., Gertler, C., Mayer, M.L.and Rosenmund, C. (2006) Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate . Journal of Neuroscience 26:7650-7658.

Yao, Y. and Mayer, M.L. (2006) Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A. Journal of Neuroscience 26:4559:4566.

Mayer, M.L. (2006) Glutamate receptors at atomic resolution. Nature 440, 456-462.

Mayer, M.L., Ghoshal. A., Dolman,N.P and Jane, D.E. (2006) Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5 Selective Antagonists. Journal of Neuroscience 26:2852:2861.

Mayer, M.L. (2005) Glutamate receptor ion channels. Current Opinion in Neurobiology 15, 282-288.

Mayer, M.L. (2005) Crystal Structures of the GluR5 and GluR6 Ligand Binding Cores: Molecular Mechanisms Underlying Kainate Receptor Selectivity. Neuron 45, 539-552. (44 citations).

Mayer, M.L. (2005) Some assembly required. Nature Structural & Molecular Biology 12, 208-209.

Horning, M.S. and Mayer, M.L. (2004) Regulation of AMPA receptor gating by ligand binding core dimers. Neuron 41: 379-388. (43 citations).

Mayer, M.L. and Armstrong, N.A. (2004) Structure and function of glutamate receptor ion channels. Annual Review of Physiology 66: 161-181. (74 citations)

Armstrong, N.A., Mayer, M.L., Gouaux, E. (2003) Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes, PNAS 100, 5736-5741. (43 citations).

Jin, R., Banke, T.G., Mayer M.L, Traynelis, S.F. and Gouaux, E. (2003) Structural basis for partial agonist action at ionotropic glutamate receptors. Nature Neuroscience 6, 803-810. (92 citations).

Jin, R., Horning, M., Mayer, M.L., Gouaux, E. (2002) Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate, Biochemistry 41, 15635-15643. (43 citations).

Hogner A., Kastrup J.S., Jin R., Liljefors T., Mayer M.L., Egebjerg J., Larsen I.K., Gouaux, E. (2002) Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core, Journal of Molecular Biology 322, 93-109 (67 citations).

Sun,Y., Olson, R., Horning, M., Mayer, M. and Gouaux, E. (2002) Mechanism of glutamate receptor desensitization, Nature 417, 245-253 (215 citations).

Panchenko, V.A., Glasser, C.R. and Mayer, M.L (2001) Structural Similarities Between Glutamate Receptor Channels and K+ Channels Examined by Scanning Mutagenesis, Journal of General Physiology 117, 345-360 (45 citations).

Mayer, M.L., Olsen, R. and Gouaux, E. (2001) Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state, Journal of Molecular Biology 311, 815-836 (67 citations).

Chen, G.Q, Cui, C., Mayer, M.L and Gouaux, E. (1999) Functional characterization of a potassium-selective prokaryotic glutamate receptor, Nature 402, 817-821. (141 citations)

Cui, C. and Mayer, M.L. (1999) Heteromeric Kainate Receptors Formed by Coassembly of GluR5 GluR6 and GluR7, Journal of Neuroscience 19, 8281-8291. (64 citations).

Partin, K.M., Fleck, M. and Mayer, M.L. (1996) AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate, Journal of Neuroscience 16, 6634-6647 (186 citations).

Bowie, D. and Mayer, M.L. (1995) Inward Rectification of Both AMPA and Kainate Subtype Glutamate Receptors by Intracellular Polyamine Mediated Ion Channel Block, Neuron 15, 453-462. (201 citations).

Partin, K.M., Bowie, D. and Mayer, M.L. (1995) Structural determinants of allosteric regulation in alternatively spliced AMPA receptors, Neuron 14, 833-843 (102 citations).

Partin, K.M., Patneau, D.K. and Mayer, M.L. (1995) Cyclothiazide Differentially Modulates Desensitization of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Splice Variants, Molecular Pharmacology 46, 129-138 (192 citations).

Patneau, D.K., Mayer, M.L. and Gallo, V. (1994) Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor, Neuron 12, 357-371. (213 citations)

McBain, C.J. and Mayer, M.L. (1994) N-Methyl-D-Aspartic acid receptor structure and function., Physiological Reviews 74, 723-760. (590 citations).

Partin, K., Patneau, D.K., Winters, C.A., Mayer, M.L. and Buonanno, A. (1993) Selective Modulation of Desensitization at AMPA versus Kainate Receptors by Cyclothiazide and Concanavalin A, Neuron 11, 1069-1082 (389 citations)

Patneau, D.K., Vyklicky, L., and Mayer, M.L. (1993).  Hippocampal-Neurons Exhibit Cyclothiazide-Sensitive Rapidly Desensitizing Responses to Kainate. Journal of Neuroscience 13, 3496-3509 (294 citations).

Vyklicky, L., Patneau, D.K. and Mayer, M.L. (1991) Modulation of Excitatory Synaptic Transmission by Drugs which Reduce Desensitization at AMPA/Kainate Receptors, Neuron 7, 971-984 (191 citations).

Patneau, D.K. and Mayer, M.L. (1991) Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons, Neuron 6, 785-798 (197 citations).

Benveniste, M. and Mayer, M.L. (1990) Kinetic-Analysis Of Antagonist Action At N-Methyl-D-Aspartic Acid Receptors - 2 Binding-Sites Each For Glutamate And Glycine. Biophysical J ournal 59, 560-573 (116 citations).

Patneau, D.K. and Mayer, M.L. (1990) Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. Journal of Neuroscience 10, 2385-2399 (398 citations).

Mayer, M.L., Vyklicky, L. and Clements, J.D. (1989) Glycine regulates NMDA receptor desensitization in mouse hippocampal neurones. Nature 338, 425-427 (305 citations)

Sernagor, E., Kuhn, D., Vyklicky, L. and Mayer, M.L. (1989) Open channel block of NMDA receptor responses evoked by Tricyclic antidepressants. Neuron 2, 1221-1227 (80 citations).

Mayer, M.L. and Vyklicky, Jr. L. (1989) Concanavalin-A selectively reduces desensitization of mammalian neuronal quisqualate receptors, PNAS 86, 1411-1415. (207 citations).

Mayer, M.L. and Westbrook, G.L (1987) The physiology of excitatory amino acids in the vertebrate central nervous system. Progress in Neurobiology 28, 197-276. (1475 citations).

Mayer, M.L. and Westbrook, G.L (1987) Permeation and block of N-methyl-D-aspartate receptors by divalent cations in mouse cultured hippocampal neurons. Journal of Physiology 394, 501-527. (641 citations).

Westbrook, G.L. and Mayer, M.L. (1987) Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of central neurons. Nature 328, 640-643. (674 citations).

MacDermott, A.B., Mayer, M.L., Westbrook, G.L., Smith, S.J. and Barker, J.L. (1986) NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321, 519-522. (1302 citations).

Mayer, M.L. (1985) A calcium-activated chloride current generates the after-depolarization of rat sensory neurones in culture. Journal of Physiology 364, 217-239. (200 citations).

Mayer, M.L., Westbrook, G.L. and Guthrie, P.B. (1984) Voltage dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309, 261-263. (1766 citations).

Mayer, M.L. and Westbrook, G.L (1983) A voltage-clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones. Journal of Physiology 340, 19-45 (362 citations).